Triazolam - CISMeF

Preferred Label : Triazolam;

NCIt synonyms : 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine; Clorazolam;

NCIt definition : A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.;

UNII : 1HM943223R;

InChIKey : JOFWLTCLBGQGBO-UHFFFAOYSA-N;

CAS number : 28911-01-5;

Drug name : Songar; Halcion; Novidorm;

Molecule name : U 33030; U-33,030;

Chemical formula : C17H12Cl2N4;

ChEBI ID : CHEBI:9674;

Details

Origin ID

C29520;

UMLS CUI

C0040879;

Automatic exact mappings (from CISMeF team)
- Triazolam [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing triazolam (medicinal product) [SNOMED CT concept]
- Triazolam [ICD-11 Extension code]
- Triazolam [LOINC component]
- Triazolam (substance) [SNOMED CT concept]
- triazolam [ATC Code]
- triazolam [Substance BNPC]
- triazolam [MeSH concept]
- triazolam [MeSH Descriptor]
- triazolam [SNOMED Notion]
Validated automatic mappings to BTNT
- triazolam [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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