Preferred Label : Transdermal Estrogen;
NCIt synonyms : Estrodiol Gel;
NCIt definition : A transdermal formulation containing the synthetic form of estradiol, the most potent,
endogenously produced estrogen. Upon topical administration, estradiol diffuses through
the cell membrane and binds to and activates specific intracellular estrogen receptors
located on estrogen-responsive tissues, including the reproductive tract, breast,
pituitary, hypothalamus, liver, and bone. The activated ligand-receptor complex binds
to estrogen response elements on DNA and promotes the transcription of genes involved
in the functioning of the female reproductive system and secondary sex characteristics.
In addition, estradiol inhibits the pituitary secretion of the gonadotropins luteinizing
hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism.;
Drug name : EstroGel; Divigel;
Origin ID : C61440;
UMLS CUI : C1831768;
Semantic type(s)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
