Preferred Label : Cytochrome P450 1A2;
NCIt synonyms : Microsomal Monooxygenase; Cytochrome-P450-1A2; Flavoprotein-Linked Monooxygenase; Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2; Cytochrome P-450, Aromatic Compound-Inducible; Xenobiotic Monooxygenase; Dioxin-Inducible P3-450; Aryl Hydrocarbon Hydroxylase; P450 Form 4; P450-P3; P(3)450; P450 4; EC 1.14.14.1; Cytochrome P450 4; Cytochrome P450-P3; Cytochrome P450, Family 1, Subfamily A, Polypeptide 2; Cytochrome P(3)450; CYPIA2; CYP1A2;
NCIt definition : Cytochrome P450 1A2 (515 aa, 58 kDa) is encoded by the human CYP1A2 gene. This protein
is involved in the hydroxylation of fatty acids, steroids and xenobiotics.;
NCIt note : Substrates for cytochrome P450 1A2 include caffeine, aflatoxin B1, acetaminophen.
carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic
amines and phenacetin. (UniProt);
Origin ID : C17673;
UMLS CUI : C1620185;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- enzyme_metabolizes_chemical_or_drug
- gene_encodes_gene_product
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
