Naproxen - CISMeF

Preferred Label : Naproxen;

NCIt synonyms : 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid; d-2-(6-Methoxy-2-naphthyl)propionic Acid;

NCIt related terms : Naprosyn;

NCIt definition : A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.;

Alternative definition : NCI-GLOSS: A drug used to treat mild pain and the symptoms of arthritis and several other conditions. It is also being studied in the treatment of bone pain in patients with cancer. Naprosyn stops the body from making substances that cause pain and inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and a type of cyclooxygenase inhibitor.;

UNII : 57Y76R9ATQ;

InChIKey : CMWTZPSULFXXJA-VIFPVBQESA-N;

CAS number : 22204-53-1;

Drug name : Naprosyn;

Molecule name : RS-3540;

Chemical formula : C14H14O3;

ChEBI ID : CHEBI:7476;

Codes from synonyms : CDR0000615394; CDR0000615395;

Details

Origin ID

C680;

UMLS CUI

C0027396;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Naproxen [ICD-11 Extension code]
- Naproxen [LOINC component]
- Naproxen (substance) [SNOMED CT concept]
- Product containing naproxen (medicinal product) [SNOMED CT concept]
- naproxen [ATC Code]
- naproxen [ATC Code]
- naproxen [ATC Code]
- naproxen [Substance BNPC]
- naproxen [MeSH concept]
- naproxen [MeSH Descriptor]
- naproxen [SNOMED Notion]
Validated automatic mappings to BTNT
- naproxen [ATC Code]
- naproxen [ATC Code]
- naproxen [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2C9 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Naproxen Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Naproxen Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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