Cytochrome P450 2C9

Preferred Label : Cytochrome P450 2C9;

NCIt synonyms : Flavoprotein-Linked Monooxygenase; Cytochrome-P450-2C9; CYP2C9; Xenobiotic Monooxygenase; Mephenytoin 4-Hydroxylase; P450 PB-1; P450 MP-4; CYPIIC9; Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 10; S-Mephenytoin 4-Hydroxylase; Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9; P-450MP; Cytochrome P450, Family 2, Subfamily C, Polypeptide 9; Microsomal Monooxygenase; Cytochrome P-450MP; EC 1.14.13.48; Cytochrome P450 MP-4; EC 1.14.13.-; Cytochrome P450 MP-8; Cytochrome P450 PB-1; (R)-Limonene 6-Monooxygenase; (S)-Limonene 7-Monooxygenase; EC 1.14.13.49; EC 1.14.13.80;

NCIt definition : Cytochrome P450 2C9 (490 aa, 56 kDa) is encoded by the human CYP2C9 gene. This protein is involved in the oxidation of fatty acids, steroids and xenobiotics.;

NCIt note : Cytochrome P450 2C9 contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. (UniProt);

Details

Origin ID

C28750;

UMLS CUI

C0608437;

Automatic exact mappings (from CISMeF team)
- (R)-Limonene 6-Monooxygenase [MeSH concept]
- (S)-Limonene 7-Monooxygenase [MeSH concept]
- 2,4-estrogen hydroxylase, human [MeSH Supplementary Concept]
- CYP102A3 protein, bacillus subtilis [MeSH Supplementary Concept]
- CYP19A1 protein, human [MeSH Supplementary Concept]
- CYP1A1 protein, human [MeSH Supplementary Concept]
- CYP1A2 protein, human [MeSH Supplementary Concept]
- CYP1A4 protein, gallus gallus [MeSH Supplementary Concept]
- CYP27C1 protein, human [MeSH Supplementary Concept]
- CYP2A10 protein, oryctolagus cuniculus [MeSH Supplementary Concept]
- CYP2A11 protein, oryctolagus cuniculus [MeSH Supplementary Concept]
- CYP2A13 protein, human [MeSH Supplementary Concept]
- CYP2A7 protein, human [MeSH Supplementary Concept]
- CYP2A8 protein, mesocricetus auratus [MeSH Supplementary Concept]
- CYP2B12 protein, rat [MeSH Supplementary Concept]
- CYP2C11 protein, rat [MeSH Supplementary Concept]
- CYP2C18 protein, human [MeSH Supplementary Concept]
- CYP2C19 protein, human [MeSH Supplementary Concept]
- CYP2C25 protein, mesocricetus auratus [MeSH Supplementary Concept]
- CYP2C26 protein, mesocricetus auratus [MeSH Supplementary Concept]
- CYP2C27 protein, mesocricetus auratus [MeSH Supplementary Concept]
- CYP2C28 protein, mesocricetus auratus [MeSH Supplementary Concept]
- CYP2C3 protein, oryctolagus cuniculus [MeSH Supplementary Concept]
- CYP2C38 protein, mouse [MeSH Supplementary Concept]
- CYP2C5 protein, oryctolagus cuniculus [MeSH Supplementary Concept]
- CYP2C8 protein, human [MeSH Supplementary Concept]
- CYP2D9 protein, mouse [MeSH Supplementary Concept]
- CYP2F1 protein, human [MeSH Supplementary Concept]
- CYP2K1 protein, oncorhynchus mykiss [MeSH Supplementary Concept]
- CYP2M1 protein, oncorhynchus mykiss [MeSH Supplementary Concept]
- CYP3A protein, human [MeSH Supplementary Concept]
- CYP3A protein, mouse [MeSH Supplementary Concept]
- CYP3A43 protein, human [MeSH Supplementary Concept]
- CYP3A5 protein, human [MeSH Supplementary Concept]
- CYP3A7 protein, human [MeSH Supplementary Concept]
- CYP4F12 protein, human [MeSH Supplementary Concept]
- CYP4F8 protein, human [MeSH Supplementary Concept]
- CYP6D1 protein, musca domestica [MeSH Supplementary Concept]
- Cyp19a1a protein, zebrafish [MeSH Supplementary Concept]
- Cyp2a1 protein, rat [MeSH Supplementary Concept]
- Cyp2a4 protein, mouse [MeSH Supplementary Concept]
- Cyp2b10 protein, mouse [MeSH Supplementary Concept]
- Cyp2b19 protein, mouse [MeSH Supplementary Concept]
- Cyp2b3 protein, rat [MeSH Supplementary Concept]
- Cyp2b9 protein, mouse [MeSH Supplementary Concept]
- Cyp2c13 protein, rat [MeSH Supplementary Concept]
- Cyp2c29 protein, mouse [MeSH Supplementary Concept]
- Cyp2c40 protein, mouse [MeSH Supplementary Concept]
- Cyp2c6v1 protein, rat [MeSH Supplementary Concept]
- Cyp2d1 protein, rat [MeSH Supplementary Concept]
- Cyp2d2 protein, rat [MeSH Supplementary Concept]
- Cyp2d4 protein, rat [MeSH Supplementary Concept]
- Cyp2j3 protein, rat [MeSH Supplementary Concept]
- Cyp3a11 protein, mouse [MeSH Supplementary Concept]
- Cyp3a13 protein, mouse [MeSH Supplementary Concept]
- Cyp3a2 protein, rat [MeSH Supplementary Concept]
- Cyp3a23-3a1 protein, rat [MeSH Supplementary Concept]
- Cyp3a25 protein, mouse [MeSH Supplementary Concept]
- Cyp3a62 protein, rat [MeSH Supplementary Concept]
- Cyp3a9 protein, rat [MeSH Supplementary Concept]
- Cyp4f1 protein, rat [MeSH Supplementary Concept]
- Cyp4f4 protein, rat [MeSH Supplementary Concept]
- Cyp4f5 protein, rat [MeSH Supplementary Concept]
- Cytochrome P-450 CYP2C8 [MeSH Descriptor]
- Cytochrome p450 CYP2C9 enzyme (substance) [SNOMED CT concept]
- Cytochrome p450, subfamily I, polypeptide 1 [OMIM gene]
- Cytochrome p450, subfamily iic, polypeptide 9 [OMIM gene]
- Erg11 protein, S cerevisiae [MeSH Supplementary Concept]
- Limonene Hydroxylases [MeSH Descriptor]
- Unspecific monooxygenase (substance) [SNOMED CT concept]
- arene monooxygenase (epoxidizing) [MeSH Supplementary Concept]
- aromatase [MeSH Descriptor]
- aryl hydrocarbon hydroxylases [MeSH Descriptor]
- aryl hydrocarbon hydroxylases [MeSH concept]
- benzphetamine N-demethylase [MeSH Supplementary Concept]
- chlorzoxazone 6-hydroxylase, rat [MeSH Supplementary Concept]
- cytochrome P-450 CYP1A3 (rainbow trout) [MeSH Supplementary Concept]
- cytochrome P-450 CYP1A5 [MeSH Supplementary Concept]
- cytochrome P-450 CYP2A16 (hamster) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2B11 (dog) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2B4 (rabbit) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2B5 (rabbit) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2D15 (dog) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2D16 (guinea pig) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2D19 (marmoset) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2D30 (marmoset) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2F3 (goat) [MeSH Supplementary Concept]
- cytochrome P-450 CYP2G1 [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A12 (canine) [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A14 (guinea pig) [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A21 (marmoset) [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A37 (chicken) [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A45 [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A6 (rabbit) [MeSH Supplementary Concept]
- cytochrome P-450 CYP3A65, zebrafish [MeSH Supplementary Concept]
- cytochrome P-450 CYP4A4 (rabbit) [MeSH Supplementary Concept]
- cytochrome P-450 CYP4B1 [MeSH Supplementary Concept]
- cytochrome P-450 CYP6B1 (butterfly) [MeSH Supplementary Concept]
- cytochrome P-450 CYP6B17, butterfly [MeSH Supplementary Concept]
- cytochrome P-450 CYP6B3 (butterfly) [MeSH Supplementary Concept]
- cytochrome P-450 CYP6B4, butterfly [MeSH Supplementary Concept]
- cytochrome P450 CYP3A10 (hamster) [MeSH Supplementary Concept]
- cytochrome P450 family 2 subfamily C member 19 [ORDO Gene]
- cytochrome P450 family 2 subfamily C member 9 [ORDO Gene]
- cytochrome p-450 cyp1a1 [MeSH Descriptor]
- cytochrome p-450 cyp1a2 [MeSH Descriptor]
- cytochrome p-450 cyp2b1 [MeSH Descriptor]
- cytochrome p-450 cyp2d6 [MeSH Descriptor]
- cytochrome p-450 cyp2e1 [MeSH Descriptor]
- cytochrome p-450 cyp3a [MeSH Descriptor]
- estrogen 2-hydroxylase [MeSH Supplementary Concept]
- prostaglandin omega hydroxylases [MeSH Supplementary Concept]
- steroid 15-alpha-hydroxylase [MeSH Supplementary Concept]
- steroid 15-beta-hydroxylase [MeSH Supplementary Concept]
- steroid 16-alpha-hydroxylase [MeSH Descriptor]
- steroid 16-beta-hydroxylase [MeSH Supplementary Concept]
- steroid hormone 6-beta-hydroxylase [MeSH Supplementary Concept]
- steroid hormone 7-alpha-hydroxylase [MeSH Supplementary Concept]
- testosterone 7-alpha-hydroxylase, hamster [MeSH Supplementary Concept]
- xenobiotic monooxygenases [MeSH concept]
Currated CISMeF NLP mapping
- Cytochrome P-450 CYP2C9 [MeSH Descriptor]
OMIM relation
- Cytochrome p450, subfamily iic, polypeptide 9 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP2C9 protein, human [MeSH Supplementary Concept]
- CYP2C9 protein, human [MeSH concept]
Validated automatic mappings to BTNT
- CYP2C9 protein, human [MeSH concept]
- CYP2C9 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
enzyme_metabolizes_chemical_or_drug
- Amitriptyline [NCIt concept]
- Amitriptyline Hydrochloride [NCIt concept]
- Amitriptyline Pamoate [NCIt concept]
- Celecoxib [NCIt concept]
- Cyclophosphamide [NCIt concept]
- Diclofenac [NCIt concept]
- Fluoxetine [NCIt concept]
- Glimepiride [NCIt concept]
- Glipizide [NCIt concept]
- Glyburide [NCIt concept]
- Ibuprofen [NCIt concept]
- Irbesartan [NCIt concept]
- Montelukast [NCIt concept]
- Naproxen [NCIt concept]
- Naproxen Sodium [NCIt concept]
- Phenytoin [NCIt concept]
- Piroxicam [NCIt concept]
- Rosiglitazone Maleate [NCIt concept]
- Tamoxifen [NCIt concept]
- Tamoxifen Citrate [NCIt concept]
- Torsemide [NCIt concept]
- Warfarin [NCIt concept]
gene_encodes_gene_product
- CYP2C9 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Fatty Acid Metabolism Pathway [NCIt concept]
- Linoleic Acid Metabolism Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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