Imipramine Hydrochloride

Preferred Label : Imipramine Hydrochloride;

NCIt synonyms : Imipramine;

NCIt definition : The hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04);

UNII : BKE5Q1J60U;

InChIKey : XZZXIYZZBJDEEP-UHFFFAOYSA-N;

CAS number : 113-52-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 113-52-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Tofranil;

Chemical formula : C19H24N2.HCl;

NSC code : 114900;

ChEBI ID : CHEBI:5882;

Codes from synonyms : 30058;

Details

Origin ID

C29116;

UMLS CUI

C0589978;

Automatic exact mappings (from CISMeF team)
- Imipramine [ICHI extension code]
- Product containing imipramine (medicinal product) [SNOMED CT concept]
- imipramine [MeSH Descriptor]
- imipramine [ATC Code]
- imipramine [Substance BNPC]
- imipramine [EMDN type]
- imipramine [medical devices type]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Imipramine [LOINC component]
- Imipramine [ICD-11 Extension code]
- Imipramine (substance) [SNOMED CT concept]
- imipramine [MeSH Descriptor]
- imipramine [Substance BNPC]
- imipramine [MeSH concept]
- imipramine [SNOMED Notion]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2C19 [NCIt concept]
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Imipramine [NCIt concept]
is_salt_form_of
- Imipramine [NCIt concept]

Keyword's position in hierarchy(ies) :

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