NCIt definition : The hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant
Imipramine enhances monoamine neurotransmission in certain areas of the brain. It
also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic
blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect
than other members of its therapeutic family. It is used in major depression, dysthymia,
bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders.
(NCI04);