Imipramine - CISMeF

Preferred Label : Imipramine;

NCIt synonyms : Imipramine Base; 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-;

NCIt definition : A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04);

UNII : OGG85SX4E4;

InChIKey : BCGWQEUPMDMJNV-UHFFFAOYSA-N;

CAS number : 50-49-7;

Chemical formula : C19H24N2;

NSC code : 169866;

ChEBI ID : CHEBI:47499;

Codes from synonyms : 30354;

Details

Origin ID

C62039;

UMLS CUI

C0020934;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Imipramine [ICD-11 Extension code]
- Imipramine [LOINC component]
- Imipramine (substance) [SNOMED CT concept]
- Product containing imipramine (medicinal product) [SNOMED CT concept]
- imipramine [ATC Code]
- imipramine [Substance BNPC]
- imipramine [MeSH concept]
- imipramine [MeSH Descriptor]
- imipramine [SNOMED Notion]
Validated automatic mappings to BTNT
- imipramine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 1A2 [NCIt concept]
- Cytochrome P450 2C19 [NCIt concept]
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Imipramine Hydrochloride [NCIt concept]
- Imipramine Pamoate [NCIt concept]
is_free_acid_or_base_form_of
- Imipramine Hydrochloride [NCIt concept]
- Imipramine Pamoate [NCIt concept]

Keyword's position in hierarchy(ies) :

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