" /> Cytochrome P450 2D6 - CISMeF





Preferred Label : Cytochrome P450 2D6;

NCIt synonyms : Flavoprotein-Linked Monooxygenase; P450-DB1; Cytochrome P450, Subfamily IID; P450-2D6; CYPIID6; Cytochrome P450, Subfamily IID-Like 1; Microsomal Monooxygenase; Xenobiotic Monooxygenase; Cytochrome P450 Subfamily IID Polypeptide 6; Debrisoquine 4-Hydroxylase; P450DB1; EC 1.14.14.1; Cytochrome P450-DB1; Cytochrome-P450-2D6;

NCIt related terms : LIVER KIDNEY MICROSOMAL TYPE 1 ANTIGEN; Liver Kidney Microsomal 1 Antigen; CYP2D6;

NCIt definition : Cytochrome P450 2D6 (497 aa, 56 kDa) is encoded by the human CYP2D6 gene. This protein plays a role in flavoprotein metabolism.;

Alternative definition : CDISC: An antigen in the cytochrome P450 mixed-function oxidase system and is encoded by the CYP2D6 gene, it is a major drug metabolizing enzyme. It can be considered as an autoantigen and is commonly associated with the autoimmune hepatitis.;

NCIt note : Cytochrome P450 2D6 localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrhythmic drugs; and amitriptyline, an anti-depressant.;

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05/05/2025


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