Preferred Label : Fluoxetine;
NCIt synonyms : N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine;
NCIt definition : A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant,
anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating
activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT)
receptor resulting in negative allosteric modulation of the receptor complex, thereby
blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin
reuptake by fluoxetine enhances serotonergic function through serotonin accumulation
in the synaptic space, resulting in long-term desensitization and downregulation of
5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant,
anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may
inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6).
This may prevent IL-6-mediated inflammation and cytokine storm.;
Alternative definition : NCI-GLOSS: A drug used to treat depression. It belongs to the family of drugs called
antidepressants.;
UNII : 01K63SUP8D;
InChIKey : RTHCYVBBDHJXIQ-UHFFFAOYSA-N;
CAS number : 54910-89-3;
Chemical formula : C17H18F3NO;
ChEBI ID : CHEBI:5118;
Codes from synonyms : CDR0000045374;
Origin ID : C506;
UMLS CUI : C0016365;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
