Preferred Label : Fluoxetine Hydrochloride;
NCIt related terms : Prozac;
NCIt definition : The hydrochloride salt form of fluoxetine, a diphenhydramine derivative and selective
serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and
antibulimic activity and with potential immunomodulating activity. Upon administration,
fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative
allosteric modulation of the receptor complex, thereby blocking recycling of serotonin
by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances
serotonergic function through serotonin accumulation in the synaptic space, resulting
in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated
signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic
effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines,
including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine
storm.;
UNII : I9W7N6B1KJ;
InChIKey : GIYXAJPCNFJEHY-UHFFFAOYSA-N;
CAS number : 59333-67-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 59333-67-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Prozac;
Chemical formula : C17H18F3NO.HCl;
NSC code : 714457;
Codes from synonyms : NSC0714457;
Origin ID : C2829;
UMLS CUI : C0733380;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
