Fluoxetine Hydrochloride

Preferred Label : Fluoxetine Hydrochloride;

NCIt related terms : Prozac;

NCIt definition : The hydrochloride salt form of fluoxetine, a diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm.;

UNII : I9W7N6B1KJ;

InChIKey : GIYXAJPCNFJEHY-UHFFFAOYSA-N;

CAS number : 59333-67-4;

Drug name : Prozac;

Chemical formula : C17H18F3NO.HCl;

NSC code : 714457;

Codes from synonyms : NSC0714457;

Details

Origin ID

C2829;

UMLS CUI

C0733380;

Automatic exact mappings (from CISMeF team)
- fluoxetine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- fluoxetine [MeSH Descriptor]
- fluoxetine [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_free_acid_or_base_form
- Fluoxetine [NCIt concept]
is_salt_form_of
- Fluoxetine [NCIt concept]

Keyword's position in hierarchy(ies) :

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