" /> Timolol Maleate - CISMeF





Preferred Label : Timolol Maleate;

NCIt definition : The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.;

UNII : P8Y54F701R;

InChIKey : WLRMANUAADYWEA-NWASOUNVSA-N;

CAS number : 26921-17-5;

Chemical formula : C13H24N4O3S.C4H4O4;

ChEBI ID : CHEBI:9600;

Codes from synonyms : 32066;

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07/05/2025


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