Preferred Label : Timolol;
NCIt synonyms : Blocadren; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-,
hemihydrate, (S)-;
NCIt definition : A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive
property. Timolol competitively binds to beta-1-adrenergic receptors in the heart
and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth
muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade
results in a decrease in resting and exercise heart rate and cardiac output, a decrease
in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex
orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular
resistance. The ultimate results include vasodilation, and negative chronotropic and
inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly
by decreasing aqueous humor production by reduction of blood flow to the ciliary processes
and cAMP synthesis.;
UNII : 817W3C6175;
InChIKey : TWBNMYSKRDRHAT-RCWTXCDDSA-N;
CAS number : 91524-16-2;
Drug name : Betimol;
Chemical formula : 2C13H24N4O3S.H2O;
ChEBI ID : CHEBI:60787;
Codes from synonyms : 30216;
Origin ID : C47757;
UMLS CUI : C0040233;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
