Doxepin Hydrochloride

Preferred Label : Doxepin Hydrochloride;

NCIt definition : A dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.;

UNII : 3U9A0FE9N5;

CAS number : 1229-29-4;

Drug name : Adapin; Sinequan;

NSC code : 108160;

Details

Origin ID

C29006;

UMLS CUI

C0700535;

Automatic exact mappings (from CISMeF team)
- doxepin [MeSH Descriptor]
Currated CISMeF NLP mapping
- DOXEPIN HYDROCHLORIDE [SMS substance]
- Doxepin hydrochloride [Substance BNPC]
- Doxepin hydrochloride (substance) [SNOMED CT concept]
- doxepin hydrochloride [MeSH concept]
- doxepin hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- doxepin [MeSH Descriptor]
- doxepin [Substance BNPC]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Doxepin [NCIt concept]
is_salt_form_of
- Doxepin [NCIt concept]

Keyword's position in hierarchy(ies) :

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