Preferred Label : Oxycodone;
NCIt synonyms : Oxycodone SR; 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one;
NCIt definition : A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone
exerts its analgesic activity by binding to the mu-receptors in the central nervous
system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the
opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and
inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the
release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric
acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also
inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition,
oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled
inwardly rectifying potassium channels resulting in hyperpolarization and reduction
of neuronal excitability.;
UNII : CD35PMG570;
InChIKey : BRUQQQPBMZOVGD-XFKAJCMBSA-N;
CAS number : 76-42-6;
Chemical formula : C18H21NO4;
NSC code : 19043;
ChEBI ID : CHEBI:7852;
Origin ID : C29309;
UMLS CUI : C0030049;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
