Nortriptyline - CISMeF

Preferred Label : Nortriptyline;

NCIt synonyms : Nortriptyline Base;

NCIt definition : A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.;

UNII : BL03SY4LXB;

InChIKey : PHVGLTMQBUFIQQ-UHFFFAOYSA-N;

CAS number : 72-69-5;

Chemical formula : C19H21N;

ChEBI ID : CHEBI:7640;

Details

Origin ID

C62060;

UMLS CUI

C0028420;

Automatic exact mappings (from CISMeF team)
- Nortriptyline [ICHI extension code]
- nortriptyline [EMDN type]
- nortriptyline [medical devices type]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nortriptyline [ICD-11 Extension code]
- Nortriptyline [LOINC component]
- Nortriptyline (substance) [SNOMED CT concept]
- Product containing nortriptyline (medicinal product) [SNOMED CT concept]
- nortriptyline [ATC Code]
- nortriptyline [Substance BNPC]
- nortriptyline [MeSH concept]
- nortriptyline [MeSH Descriptor]
- nortriptyline [SNOMED Notion]
Validated automatic mappings to BTNT
- nortriptyline [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Nortriptyline Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Nortriptyline Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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