Nortriptyline Hydrochloride

Preferred Label : Nortriptyline Hydrochloride;

NCIt synonyms : 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, Hydrochloride; Nortriptyline;

NCIt definition : The hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.;

UNII : 00FN6IH15D;

InChIKey : SHAYBENGXDALFF-UHFFFAOYSA-N;

CAS number : 894-71-3;

Drug name : Pamelor; Allegron; Norpress;

Chemical formula : C19H21N.HCl;

NSC code : 169453;

Details

Origin ID

C704;

UMLS CUI

C0700459;

Automatic exact mappings (from CISMeF team)
- Nortriptyline [ICHI extension code]
- Product containing nortriptyline (medicinal product) [SNOMED CT concept]
- nortriptyline [ATC Code]
- nortriptyline [EMDN type]
- nortriptyline [medical devices type]
Currated CISMeF NLP mapping
- Nortriptyline hydrochloride [Substance BNPC]
- Nortriptyline hydrochloride (substance) [SNOMED CT concept]
- nortriptyline hydrochloride [MeSH concept]
- nortriptyline hydrochloride [SNOMED Notion]
See also inter- (CISMeF)
- Nortriptyline hydrochloride (product) [Inactive SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nortriptyline hydrochloride [Substance BNPC]
- Nortriptyline hydrochloride (product) [Inactive SNOMED CT concept]
- Nortriptyline hydrochloride (substance) [SNOMED CT concept]
- nortriptyline hydrochloride [MeSH concept]
- nortriptyline hydrochloride [SNOMED Notion]
Validated automatic mappings to NTBT
- Nortriptyline [LOINC component]
- Nortriptyline [ICD-11 Extension code]
- Nortriptyline (substance) [SNOMED CT concept]
- nortriptyline [MeSH concept]
- nortriptyline [SNOMED Notion]
- nortriptyline [Substance BNPC]
- nortriptyline [MeSH Descriptor]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2D6 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Nortriptyline [NCIt concept]
is_salt_form_of
- Nortriptyline [NCIt concept]

Keyword's position in hierarchy(ies) :

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