cytochrome p-450 cyp2d6

Preferred Label : cytochrome p-450 cyp2d6;

MeSH definition : A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.;

MeSH synonym : imipramine 2-hydroxylase; debrisoquine 4-monooxygenase; monooxygenase, sparteine; p450 2d6, cytochrome; 4-hydroxylase, debrisoquine; hydroxylase, debrisoquine; sparteine monooxygenase; cyp2d6; cytochrome p450 2d6; 4-monooxygenase, debrisoquine; debrisoquine 4 monooxygenase; debrisoquine hydroxylase; 2-hydroxylase, imipramine; imipramine 2 hydroxylase; cyp 2d6; debrisoquine 4-hydroxylase; debrisoquine 4 hydroxylase; cyp2d6, cytochrome p-450; p-450 cyp2d6, cytochrome; cytochrome P 450 CYP2D6;

Registry Number MeSH : EC 1.14.14.1;

MeSH annotation : do not confuse with other cytochrome P-450 CYP's;

Wikipedia link : https://en.wikipedia.org/wiki/Cytochrome p-450 cyp2d6;

Is substance : O;

UNII : EC 1.14.14.1;

Details

Origin ID

D019389;

UMLS CUI

C0057223;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cytochrome P450 2D6 [NCIt concept]
- Cytochrome p450 CYP2D6 enzyme (substance) [SNOMED CT concept]
Indexing information
- 1-((2-ethyl-4-methyl-1H-imidazol-5-yl)methyl)-4-(4-(trifluoromethyl)-2-pyridinyl)piperazine [MeSH Supplementary Concept]
- 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin [MeSH Supplementary Concept]
- dextromethorphan O-demethylase [MeSH Supplementary Concept]
- methylenedoxyamphetamine demethylenase [MeSH Supplementary Concept]
Record concept(s)
- cytochrome P-450 CYP2D6 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP2D6 protein, human [MeSH Supplementary Concept]
- drug metabolism, poor, CYP2D6-Related [MeSH Supplementary Concept]
Related MeSH term(s)
- Cytochrome P-450 CYP2D6 Inhibitors [MeSH Descriptor]
See also (suggested by CISMeF)
- Cytochrome P-450 CYP2D6 Inducers [MeSH Descriptor]
- Cytochrome P-450 CYP2D6 Inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cytochrome p450 CYP2D6 enzyme (substance) [SNOMED CT concept]

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