Preferred Label : cytochrome P-450 enzyme system;
MeSH definition : A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic
spectrum, from animals, plants, fungi, to bacteria. They include numerous complex
monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve
two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2)
metabolism of endogenous and a wide variety of exogenous substrates, such as toxins
and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities
rather than functions, into CYP gene families ( 40% homology) and subfamilies ( 59%
homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible
for most drug metabolism.;
MeSH synonym : cytochrome p-450; cytochrome p450; cytochrome P 450 enzyme system; Cytochrome P-450 Enzymes; Cytochrome P 450 Enzymes; Enzymes, Cytochrome P-450; P-450 Enzymes, Cytochrome; P-450 Enzymes; Enzymes, P-450; P 450 Enzymes; P450 Enzymes; Enzymes, P450; Cytochrome P 450; CYP450 Family; Cytochrome P450 Superfamily; Superfamily, Cytochrome P450; Cytochrome P-450 Superfamily; Cytochrome P 450 Superfamily; Superfamily, Cytochrome P-450; Cytochrome p450 Families; Cytochrome P-450 Families; Cytochrome P 450 Families; CYP450 Superfamily; Superfamily, CYP450; P450 Enzyme; Enzyme, P450; Cytochrome P-450 Enzyme; Cytochrome P 450 Enzyme; Enzyme, Cytochrome P-450; P-450 Enzyme, Cytochrome; P-450 Enzyme; Enzyme, P-450; P 450 Enzyme;
MeSH hyponym : cytochrome P-450 monooxygenase; cytochrome P-450 oxygenase; Cytochrome P 450 Monooxygenase; Monooxygenase, Cytochrome P-450; Cytochrome P-450-Dependent Monooxygenase; Cytochrome P 450 Dependent Monooxygenase; Monooxygenase, Cytochrome P-450-Dependent; Cytochrome P 450 Oxygenase;
MeSH CAS label : cytochrome P 450;
Registry Number MeSH : 9035-51-2;
MeSH annotation : general or unspecified; prefer specific cytochrome P-450's;
Is substance : O;
Origin ID : D003577;
UMLS CUI : C0010762;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Indexing information
- CB 7645 [MeSH Supplementary Concept]
Record concept(s)
Related MeSH Supplementary Concept(s)
Related MeSH term(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic
spectrum, from animals, plants, fungi, to bacteria. They include numerous complex
monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve
two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2)
metabolism of endogenous and a wide variety of exogenous substrates, such as toxins
and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities
rather than functions, into CYP gene families ( 40% homology) and subfamilies ( 59%
homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible
for most drug metabolism.
https://www.pharmacoclin.ch/_library/pdf/2008_35_6.pdf
2008
Switzerland
French
drug interactions
cytochrome P-450 enzyme system
cytochrome p-450 cyp2d6
CYP2C9 protein, human
CYP2C19 protein, human
aryl hydrocarbon hydroxylases
drug interactions
journal article
---
https://www.cadth.ca/sites/default/files/pdf/375_armplichip_cetap_e.pdf
https://www.cadth.ca/sites/default/files/pdf/375_armplichip_f_cetap.pdf
2006
Canada
English
French
aryl hydrocarbon hydroxylases
canada
costs and cost analysis
pharmacogenetics
pharmacogenetics
genotype
united states
cytochrome p-450 cyp2d6
cytochrome P-450 enzyme system
polymorphism, genetic
CYP2C19 protein, human
aryl hydrocarbon hydroxylases
health technology assessment
---
http://afssaps.sante.fr/Dossiers-thematiques/Interactions-medicamenteuses/Interactions-medicamenteuses-et-cytochromes/
2005
France
French
pharmaceutical preparations
biotransformation
cytochrome p-450 cyp2d6
drug interactions
cytochrome p-450 cyp1a2
taxoids
cytochrome P-450 enzyme system
CYP2C8 protein, human
CYP3A4 protein, human
aryl hydrocarbon hydroxylases
cytochrome p-450 cyp3a
drug information
---