cytochrome p-450 cyp3a

Preferred Label : cytochrome p-450 cyp3a;

MeSH definition : A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.;

MeSH synonym : cyp3a; cytochrome p450 3a; erythromycin n-demethylase; p-450iiia, cytochrome; p-450 cyp3a, cytochrome; erythromycin n demethylase; n-demethylase, erythromycin; p450 3a, cytochrome; cytochrome p-450iiia; cytochrome p 450iiia; cytochrome P 450 CYP3A;

MeSH hyponym : Cytochrome P-450 CYP3A5; Cytochrome P-450 CYP3A4; Cytochrome P 450 CYP3A5; P-450 CYP3A5, Cytochrome; CYP3A5; Cytochrome P450 3A5; 3A5, Cytochrome P450; P450 3A5, Cytochrome; Cytochrome P 450 CYP3A4; P-450 CYP3A4, Cytochrome; Cytochrome P450 3A4; Taurochenodeoxycholate 6-alpha-Monooxygenase; 6-alpha-Monooxygenase, Taurochenodeoxycholate; Taurochenodeoxycholate 6 alpha Monooxygenase; CYP3A4;

MeSH Related Number : EC 1.14.13.97; EC 1.14.14.1;

Registry Number MeSH : EC 1.14.14.1;

Is substance : O;

UNII : EC 1.14.14.1;

Details

Origin ID

D051544;

UMLS CUI

C0059563;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- (3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol [MeSH Supplementary Concept]
- (7R)-7-hydroxytaxiresinol [MeSH Supplementary Concept]
- 2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone [MeSH Supplementary Concept]
- BAS 100 [MeSH Supplementary Concept]
- curcumenol [MeSH Supplementary Concept]
Record concept(s)
- Cytochrome P-450 CYP3A4 [MeSH concept]
- Cytochrome P-450 CYP3A5 [MeSH concept]
- cytochrome P-450 CYP3A [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP3A protein, human [MeSH Supplementary Concept]
- CYP3A protein, mouse [MeSH Supplementary Concept]
- CYP3A1 protein, mouse [MeSH Supplementary Concept]
- CYP3A4 protein, human [MeSH Supplementary Concept]
- CYP3A5 protein, human [MeSH Supplementary Concept]
- CYP3A7 protein, human [MeSH Supplementary Concept]
- Cyp3a11 protein, mouse [MeSH Supplementary Concept]
- Cyp3a13 protein, mouse [MeSH Supplementary Concept]
- Cyp3a2 protein, rat [MeSH Supplementary Concept]
- Cyp3a23-3a1 protein, rat [MeSH Supplementary Concept]
- Cyp3a25 protein, mouse [MeSH Supplementary Concept]
- cytochrome P450 3A4, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- Cytochrome P-450 CYP3A Inhibitors [MeSH Descriptor]
See also (suggested by CISMeF)
- Cytochrome P-450 CYP3A Inducers [MeSH Descriptor]
- Cytochrome P-450 CYP3A Inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cytochrome p450 CYP3A enzyme (substance) [SNOMED CT concept]
Validated automatic mappings to BTNT
- Cytochrome P450 3A4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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