Preferred Label : ATP Binding Cassette Transporter, Subfamily B, Member 1;
MeSH definition : A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE
TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals,
including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated
with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).;
MeSH synonym : mdr1 protein; pgy 1 protein; pgy-1 protein; multidrug resistance protein 1; P glycoprotein; CD243 Antigen; Antigen, CD243; P-Glycoprotein; ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1;
CISMeF acronym : p-gp;
MeSH hyponym : ABCB1, ATP-Dependent Translocase; ATP Dependent Translocase ABCB1; Translocase ABCB1, ATP-Dependent; P-Glycoprotein 1; 1, P-Glycoprotein; P Glycoprotein 1; MDR1B Protein; Protein, MDR1B;
MeSH annotation : P-GLYCOPROTEINS is also available; note entry term: ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B is also available; note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available;
Wikipedia link : https://en.wikipedia.org/wiki/P-glycoprotein;
Is substance : O;
Origin ID : D020168;
UMLS CUI : C0242643;
Allowable qualifiers
Indexing information
- AHC 93 [MeSH Supplementary Concept]
Record concept(s)
Related MeSH Supplementary Concept(s)
Related MeSH term(s)
See also
Semantic type(s)
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE
TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals,
including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated
with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
http://www.cbip.be/Folia/Index.cfm?FoliaWelk=F36F11F
2009
Belgium
Dutch
French
ATP Binding Cassette Transporter, Subfamily B, Member 1
drug interactions
cytochrome p-450 cyp3a
colchicine
journal article
pharmacovigilance note
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