ATP Binding Cassette Transporter, Subfamily B, Member 1

Preferred Label : ATP Binding Cassette Transporter, Subfamily B, Member 1;

MeSH definition : A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).;

MeSH synonym : mdr1 protein; pgy 1 protein; pgy-1 protein; multidrug resistance protein 1; P glycoprotein; CD243 Antigen; Antigen, CD243; P-Glycoprotein; ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1;

CISMeF acronym : p-gp;

MeSH hyponym : ABCB1, ATP-Dependent Translocase; ATP Dependent Translocase ABCB1; Translocase ABCB1, ATP-Dependent; P-Glycoprotein 1; 1, P-Glycoprotein; P Glycoprotein 1; MDR1B Protein; Protein, MDR1B;

MeSH annotation : P-GLYCOPROTEINS is also available; note entry term: ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B is also available; note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available;

Wikipedia link : https://en.wikipedia.org/wiki/P-glycoprotein;

Is substance : O;

Details

Origin ID

D020168;

UMLS CUI

C0242643;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 15-bromoparguer-9(11)-ene-2,7,16,19-tetrol-2,7,16,19-tetraacetate [MeSH Supplementary Concept]
- 15-bromoparguer-9(11)-ene-2,7,16,19-tetrol-2,7,16-triacetate [MeSH Supplementary Concept]
- 4-chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide [MeSH Supplementary Concept]
- 4-oxo-4H-chromene-2-carboxylic acid (2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)amide [MeSH Supplementary Concept]
- 6,7-dimethoxy-2-(4-methoxybiphenyl-4-yl-methyl)-1,2,3,4-tetrahydroisoquinoline [MeSH Supplementary Concept]
- AHC 93 [MeSH Supplementary Concept]
- BPR-DC-2 compound [MeSH Supplementary Concept]
- CP 147673 [MeSH Supplementary Concept]
- CP 162398 [MeSH Supplementary Concept]
- CP 172732 [MeSH Supplementary Concept]
- N-1-benzyl-2,3-dihydro-1H-pyrrolo(2,3-b)quinolin-4-yl-2-phenylacetamide [MeSH Supplementary Concept]
- SB T-101187 [MeSH Supplementary Concept]
- SB T-1250 [MeSH Supplementary Concept]
- Syl611 compound [MeSH Supplementary Concept]
- cyclic-tris-(R)-valineselenazole [MeSH Supplementary Concept]
- euphomelliferene A [MeSH Supplementary Concept]
- euphomelliferene B [MeSH Supplementary Concept]
- euphomelliferine [MeSH Supplementary Concept]
- laniquidar [MeSH Supplementary Concept]
- rivulobirin A [MeSH Supplementary Concept]
- tt12 protein, arabidopsis [MeSH Supplementary Concept]
- valspodar [MeSH Supplementary Concept]
Record concept(s)
- ATP Binding Cassette Transporter, Subfamily B, Member 1 [MeSH concept]
- ATP-Dependent Translocase ABCB1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- ABCB1 protein, human [MeSH Supplementary Concept]
- ABCB5 protein, human [MeSH Supplementary Concept]
- Abcb1b protein, mouse [MeSH Supplementary Concept]
- EhPgp5 protein, entamoeba histolytica [MeSH Supplementary Concept]
- Mdr1b protein, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- ATP Binding Cassette Transporter, Subfamily B [MeSH Descriptor]
See also
- drug resistance, multiple [MeSH Descriptor]
- genes, mdr [MeSH Descriptor]
- rhodamine 123 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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