ATP Binding Cassette Transporter, Subfamily B

Preferred Label : ATP Binding Cassette Transporter, Subfamily B;

MeSH definition : A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.; A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.; A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.; A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.;

MeSH synonym : atp-binding cassette, sub-family b proteins; atp binding cassette, sub family b proteins; multidrug resistance proteins; P glycoproteins; ATP Binding Cassette Transporter, Sub Family B; P-Glycoproteins; ATP Binding Cassette Transporter, Sub-Family B;

MeSH annotation : P-GLYCOPROTEIN is also available; P stands for permeability; note entry term: ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 is also available; note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available;

Is substance : O;

Details

Origin ID

D018435;

UMLS CUI

C0069906;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- ABC-type xenobiotic transporter activity [GO term]
- Multidrug Resistance Protein 1 [NCIt concept]
- PGP Gene [NCIt concept]
- Phosphoglycolate Phosphatase [NCIt concept]
- Phosphoglycolate phosphatase [OMIM gene]
Indexing information
- 4-((5,6,7,8-tetrahydro-4-oxo-4H-(1)benzothieno(2,3-d)(1,3)thiazin-2-yl)amino)benzoic acid [MeSH Supplementary Concept]
- PHII-7 compound [MeSH Supplementary Concept]
- TagB protein, dictyostelium [MeSH Supplementary Concept]
MeSH Descriptor(s) used for indexing
- ATP Binding Cassette Transporter, Subfamily B, Member 1 [MeSH Descriptor]
Record concept(s)
- ATP Binding Cassette Transporter, Subfamily B [MeSH concept]
Related MeSH Supplementary Concept(s)
- ABCB1 protein, human [MeSH Supplementary Concept]
- ABCB14 protein, arabidopsis [MeSH Supplementary Concept]
- ABCB5 protein, human [MeSH Supplementary Concept]
- ABCB5 protein, mouse [MeSH Supplementary Concept]
- Abcb1b protein, mouse [MeSH Supplementary Concept]
- Abcb4 protein, rat [MeSH Supplementary Concept]
- At1g67700 protein, Arabidopsis [MeSH Supplementary Concept]
- MD1 protein, mycoplasma hominis [MeSH Supplementary Concept]
- MD2 protein, mycoplasma hominis [MeSH Supplementary Concept]
- MRP-5 protein, C elegans [MeSH Supplementary Concept]
- P-glycoprotein 2 [MeSH Supplementary Concept]
- PGP-2 protein, C elegans [MeSH Supplementary Concept]
- PGP-3 protein, C elegans [MeSH Supplementary Concept]
- Pgp-12 protein, C elegans [MeSH Supplementary Concept]
- Pgp3 protein, sus scrofa [MeSH Supplementary Concept]
- Pgp4 protein, arabidopsis [MeSH Supplementary Concept]
- SilP protein, salmonella typhimurium [MeSH Supplementary Concept]
- cholestasis, progressive familial intrahepatic 3 [MeSH Supplementary Concept]
- mdr49 protein, drosophila [MeSH Supplementary Concept]
- mdr65 protein, drosophila [MeSH Supplementary Concept]
- multidrug resistance protein 3 [MeSH Supplementary Concept]
- multidrug resistance protein 50, drosophila [MeSH Supplementary Concept]
See also
- drug resistance, multiple [MeSH Descriptor]
- genes, mdr [MeSH Descriptor]
- multidrug Resistance-Associated proteins [MeSH Descriptor]
- rhodamine 123 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

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A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.