multidrug Resistance-Associated proteins

Preferred Label : multidrug Resistance-Associated proteins;

MeSH definition : A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.; A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 family of proteins.; A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.;

MeSH synonym : multidrug resistance associated protein; atp-binding cassette, sub-family c proteins; multispecific organic anion transporter; multispecific organic anion transport proteins; moat protein; multidrug resistance-associated protein; resistance-associated protein, multidrug; atp binding cassette, sub family c proteins; multidrug resistance associated proteins;

Is substance : O;

Details

Origin ID

D027425;

UMLS CUI

C0290741;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Atp-binding cassette, subfamily C, member 1 [OMIM gene]
- Multidrug Resistance-Associated Protein 1 [NCIt concept]
Indexing information
- verlukast [MeSH Supplementary Concept]
Record concept(s)
- multidrug Resistance-Associated proteins [MeSH concept]
Related MeSH Supplementary Concept(s)
- ABCC10 protein, human [MeSH Supplementary Concept]
- ABCC4 protein, human [MeSH Supplementary Concept]
- ABCC5 protein, human [MeSH Supplementary Concept]
- ABCC5 protein, zebrafish [MeSH Supplementary Concept]
- ABCC6 protein, human [MeSH Supplementary Concept]
- ATMRP5 protein, arabidopsis [MeSH Supplementary Concept]
- Abcc10 protein, mouse [MeSH Supplementary Concept]
- Abcc4 protein, mouse [MeSH Supplementary Concept]
- Abcc4 protein, rat [MeSH Supplementary Concept]
- Abcc4 protein, zebrafish [MeSH Supplementary Concept]
- Abcc5 protein, mouse [MeSH Supplementary Concept]
- Abcc5 protein, rat [MeSH Supplementary Concept]
- Abcc6 protein, mouse [MeSH Supplementary Concept]
- Abcc6 protein, rat [MeSH Supplementary Concept]
- AcrB protein, E coli [MeSH Supplementary Concept]
- BaeR protein, salmonella typhimurium [MeSH Supplementary Concept]
- BaeS protein, salmonella typhimurium [MeSH Supplementary Concept]
- CDR-2 protein, Candida albicans [MeSH Supplementary Concept]
- DrrA protein, streptomyces peucetius [MeSH Supplementary Concept]
- DrrB protein, streptomyces peucetius [MeSH Supplementary Concept]
- HV126 protein, human [MeSH Supplementary Concept]
- LmrA protein, lactococcus lactis [MeSH Supplementary Concept]
- LmrC protein, lactococcus lactis [MeSH Supplementary Concept]
- LmrD protein, lactococcus lactis [MeSH Supplementary Concept]
- MRP-4 protein, C elegans [MeSH Supplementary Concept]
- MRP4 protein, drosophila [MeSH Supplementary Concept]
- MRP6 protein, arabidopsis [MeSH Supplementary Concept]
- Mdr1 protein, plasmodium falciparum [MeSH Supplementary Concept]
- Mdr1 protein, plasmodium vivax [MeSH Supplementary Concept]
- Mdr2 protein, plasmodium falciparum [MeSH Supplementary Concept]
- NorA protein, staphylococcus [MeSH Supplementary Concept]
- RamA protein, salmonella typhimurium [MeSH Supplementary Concept]
- RamR protein, Salmonella typhimurium [MeSH Supplementary Concept]
- Slco2b1 protein, rat [MeSH Supplementary Concept]
- TolC protein, legionella pneumophila [MeSH Supplementary Concept]
- mrp-7 protein, C elegans [MeSH Supplementary Concept]
- multi-resistance associated protein 1, zebrafish [MeSH Supplementary Concept]
- multidrug resistance transporter STY2458, Salmonella typhi [MeSH Supplementary Concept]
- multidrug resistance-associated protein 1 [MeSH Supplementary Concept]
- multidrug resistance-associated protein 3 [MeSH Supplementary Concept]
See also
- ATP Binding Cassette Transporter, Subfamily B [MeSH Descriptor]
- drug resistance, multiple [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

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A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 family of proteins.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.