MeSH definition : The chemical alteration of an exogenous substance by or in a biological system. The
alteration may inactivate the compound or it may result in the production of an active
metabolite of an inactive parent compound. The alterations may be divided into METABOLIC
DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.;
MeSH annotation : restrict to chemical changes of exogenous substances; IM general only; coordinate
NIM with specific drug /pharmacokin (IM) or /metab; do not confuse with BIODEGRADATION,
ENVIRONMENTAL;
Wikipedia link : https://en.wikipedia.org/wiki/Biotransformation;
The chemical alteration of an exogenous substance by or in a biological system. The
alteration may inactivate the compound or it may result in the production of an active
metabolite of an inactive parent compound. The alterations may be divided into METABOLIC
DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
http://www.academie-medecine.fr/pharmacogenetique-et-pharmacogenomique-rapport-06-01/ 2006 false false France English French antivitamins K anticoagulants vitamin K immunosuppressive agents antineoplastic agents mutation pharmacogenetics genomics polymorphism, genetic iatrogenic disease Drug-Related side effects and adverse reactions genotype pharmaceutical preparations biotransformation iatrogenic disease antivitamins K guidelines indenes 4-hydroxycoumarins