Cytochrome P450

Preferred Label : Cytochrome P450;

NCIt synonyms : P450; Cytochrome P450 Family; CYP450; Cytochrome P-450; CYP; Cytochrome P450 Enzyme; Cytochrome P450 Protein; Cytochrome-P450;

NCIt related terms : cytochrome P450 enzyme system;

NCIt definition : A family of cytochromes that are involved in electron transport and oxidative metabolism of drugs and other bioactive molecules. When the catalytic heme is reduced the absorbance peak for this protein occurs at 450 nm.;

Alternative definition : NCI-GLOSS: A group of enzymes involved in drug metabolism and found in high levels in the liver. These enzymes change many drugs, including anticancer drugs, into less toxic forms that are easier for the body to excrete.;

ChEBI ID : CHEBI:38559;

Codes from synonyms : CDR0000390266;

Details

Origin ID

C16484;

UMLS CUI

C0010762;

Biochemical function of gene products
- Cytochrome P450 2A5 [NCIt concept]
- Cytochrome P450 2D5 [NCIt concept]
- Cytochrome P450 Family 11 [NCIt concept]
Currated CISMeF NLP mapping
- cytochrome P-450 enzyme system [MeSH Descriptor]
- cytochrome P-450 enzyme system [MeSH concept]
- obsolete cytochrome P450 [GO term]
False automatic mappings
- cytochrome P450 [IUPAC Term]
- cytochrome P450(C-MF) [MeSH concept]
- cytochrome P450(C-MF) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cytochrome p450 enzyme (substance) [SNOMED CT concept]
- cytochrome P-450 enzyme system [MeSH concept]
- cytochrome P-450 enzyme system [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_chemical_classification_of_gene_product
- Prostacyclin Synthase [NCIt concept]

Keyword's position in hierarchy(ies) :

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