Prostacyclin Synthase

Preferred Label : Prostacyclin Synthase;

NCIt synonyms : Prostaglandin I2 Synthase; EC 5.3.99.4; PTGIS;

NCIt definition : Prostacyclin synthase (500 aa, 57 kDa) is encoded by the human PTGIS gene. This protein plays a role in the mediation of prostaglandin biosynthesis.;

NCIt note : Prostacyclin synthase is a member of the Cytochrome P450 family but has the enzymatic activity of an isomerase.;

Details

Origin ID

C96440;

UMLS CUI

C1257995;

Automatic exact mappings (from CISMeF team)
- Prostacyclin synthase (substance) [SNOMED CT concept]
- Prostaglandin i2 synthase [OMIM gene]
- prostacyclin synthase [SNOMED Notion]
- prostacyclin synthetase [MeSH Supplementary Concept]
- prostaglandin I2 synthase [HGNC gene]
OMIM relation
- Prostaglandin i2 synthase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cytochrome p450 CYP8A1 enzyme (substance) [SNOMED CT concept]
- PTGIS protein, human [MeSH Supplementary Concept]
- PTGIS protein, human [MeSH concept]
- Prostacyclin synthase (substance) [SNOMED CT concept]
- prostacyclin synthase [SNOMED Notion]
- prostacyclin synthetase [MeSH Supplementary Concept]
- prostacyclin synthetase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- PTGIS Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Isomerase [NCIt concept]
gene_product_has_chemical_classification
- Cytochrome P450 [NCIt concept]
- Heme Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Eicosanoid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Oxidation/Reduction [NCIt concept]
- Prostaglandin Production [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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