" /> Paroxetine Hydrochloride - CISMeF





Preferred Label : Paroxetine Hydrochloride;

NCIt synonyms : (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride;

NCIt related terms : Paxil; PAROXETINE HYDROCHLORIDE ANHYDROUS;

NCIt definition : The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.;

Alternative definition : NCI-GLOSS: A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).;

UNII : 3I3T11UD2S;

InChIKey : GELRVIPPMNMYGS-RVXRQPKJSA-N;

CAS number : 78246-49-8;

Drug name : Paxil CR; Paxil;

Chemical formula : C19H20FNO3.HCl;

Codes from synonyms : CDR0000410750; CDR0000045553;

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29/04/2025


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