" /> Tamoxifen - CISMeF





Preferred Label : Tamoxifen;

NCIt synonyms : 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; Tamoxifen Base; TMX;

NCIt definition : An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.;

Alternative definition : NCI-GLOSS: A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen.;

UNII : 094ZI81Y45;

InChIKey : NKANXQFJJICGDU-QPLCGJKRSA-N;

CAS number : 10540-29-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 10540-29-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C26H29NO;

ChEBI ID : CHEBI:41774;

Codes from synonyms : NSC0180973; 00273; CDR0000045576; 479;

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12/05/2024


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