" /> Estrogen Receptor - CISMeF





Preferred Label : Estrogen Receptor;

NCIt synonyms : Estrogen Receptor Alpha; ER; ERalpha; ER-Alpha; ESR1; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; Estrogen Receptor 1; ERa; Estrogen Nuclear Receptor Alpha; NR3A1;

NCIt definition : Estrogen receptor (595 aa, 66 kDa) is encoded by the human ESR1 gene. This protein plays a role in the regulation of estradiol-dependent gene transcription.;

Alternative definition : NCI-GLOSS: A protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone estrogen will bind to the receptors inside the cells and may cause the cells to grow.;

NCIt note : ESR1 binds DNA as a homodimer or as a heterodimer with ESR2 and interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR1 complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation.;

Codes from synonyms : CDR0000046409; CDR0000044402;

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Keyword's position in hierarchy(ies) : arborescence

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01/05/2024


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