Preferred Label : Conjugated Estrogens/Bazedoxifene;
NCIt synonyms : CE/BZA Formulation; CE/BZA;
NCIt definition : A combination preparation of conjugated estrogens and the selective estrogen receptor
modulator (SERM) bazedoxifene that can be used for hormone replacement purposes. The
conjugated estrogens increase the diminishing levels of estrogen in menopausal and
postmenopausal women by binding to and activating estrogen receptors (ERs), which,
in turn, bind to estrogen response elements (EREs) in target genes; this results in
the transcription of estrogen-regulated genes. Maintaining adequate estrogen levels
decreases symptoms such as hot flashes, night sweats, irregular menstruation, fat
redistribution, mood swings, sleep disorders, vaginal dryness and osteoporosis. Bazedoxifene
specifically binds to and activates ERs in certain tissues, including liver, bone,
breast, and endometrium, and also promotes the transcription of estrogen-regulated
genes in these tissues. However, bazedoxifene acts as an estrogen antagonist in uterine
and breast tissue, thereby blocking the proliferative effects of estrogen-binding
to ER-positive cells in these tissues.;
Drug name : Duavee;
Origin ID : C125604;
UMLS CUI : C3668765;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
