Preferred Label : Estrogen Receptor Agonist GTx-758;
NCIt related terms : GTX-758;
NCIt definition : An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with
potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses
the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing
hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition
of LH secretion prevents the synthesis of androgens, including testosterone, by the
testes. This may result in suppressed total serum testosterone to the levels observed
in castration.;
UNII : 406GR1485Z;
CAS number : 938067-78-8;
Drug name : Capesaris;
Molecule name : GTx-758;
Origin ID : C96432;
UMLS CUI : C3272775;
Semantic type(s)
- concept_is_in_subset
- has_target
