Preferred Label : Autologous Native ESR1-pulsed DC1 Vaccine Alternating with Autologous Mutated ESR1-pulsed
DC1 Vaccine;
NCIt synonyms : Autologous Native ESR1-pulsed DC1s/Mutated ESR1-pulsed DC1s; Autologous DC1s Pulsed with Native or Mutated ESR1;
NCIt definition : A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized
dendritic cells (DC1s) pulsed with either native or mutated estrogen receptor alpha
(ERa; estrogen receptor 1; ESR1), with potential immunomodulatory and antineoplastic
activities. Autologous DCs were treated to produce DC1s and pulsed with either native
or mutated ESR1. Alternating weekly between autologous native ESR1-pulsed and mutated
ESR1-pulsed DC1 vaccine, upon administration, the autologous native and/or mutated
ESR1-pulsed DC1 vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response
against ESR1-positive tumor cells, which may result in tumor cell death and decreased
tumor growth. ESR1 is overexpressed and/or mutated in certain cancers.;
Origin ID : C212039;
concept_is_in_subset
- has_target
