Preferred Label : Fulvestrant;
NCIt synonyms : 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol;
NCIt related terms : Faslodex(ICI 182,780); ICI 182780; Faslodex;
NCIt definition : A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist
effects) and the aromatase inhibitors (which reduce the estrogen available to tumor
cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells,
resulting in estrogen receptor deformation and decreased estrogen binding. In vitro
studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant,
estrogen-sensitive, human breast cancer cell lines. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat certain types of breast cancer in postmenopausal women.
It is also being studied in the treatment of other types of cancer. Faslodex blocks
estrogen activity in the body and is a type of antiestrogen.;
UNII : 22X328QOC4;
InChIKey : VWUXBMIQPBEWFH-WCCTWKNTSA-N;
CAS number : 129453-61-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 129453-61-8
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G-SRS /a ;
Drug name : Faslodex;
Molecule name : ZD9238; ICI 182,780;
Chemical formula : C32H47F5O3S;
NSC code : 719276;
ChEBI ID : CHEBI:31638;
Codes from synonyms : CDR0000306498; NSC0719276; CDR0000415316; 20048; CDR0000045005; 237;
Origin ID : C1379;
UMLS CUI : C0935916;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
