Tert Regulation Pathway

Preferred Label : Tert Regulation Pathway;

NCIt related terms : Overview of telomerase protein component gene hTert Transcriptional Regulation;

Alternative definition : BIOCARTA: Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERT gene is expressed at low levels in cancer cells and is generally undetectable in normal cells. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tertpathway;

Details

Origin ID

C39249;

UMLS CUI

C1515279;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cellular Tumor Antigen p53 [NCIt concept]
- Estrogen Receptor [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- MAX Dimerization Protein 1 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Protein Max [NCIt concept]
- Transcription Factor Sp1 [NCIt concept]
- Transcription Factor Sp3 [NCIt concept]
- Wilms Tumor Protein [NCIt concept]
pathway_has_gene_element
- ESR1 wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- MAX wt Allele [NCIt concept]
- MXD1 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- SP1 wt Allele [NCIt concept]
- SP3 wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]
- WT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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