MAX Dimerization Protein 1

Preferred Label : MAX Dimerization Protein 1;

NCIt synonyms : Max Dimerizer 1; Protein MAD; MAX Dimerization Protein-1;

NCIt definition : Max dimerization protein 1 (221 aa, 26 kDa) is encoded by the human MXD1 gene. This protein is involved in the negative regulation of transcription.;

NCIt note : MAD competes with MYC for binding to MAX. MAD acts as a transcriptional repressor while MYC appears to function as an activator and is a candidate tumor suppressor gene.;

Details

Origin ID

C28627;

UMLS CUI

C1334486;

OMIM relation
- Max dimerization protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MXD1 protein, human [MeSH concept]
- MXD1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- MXD1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- HDAC Class I Signaling Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Tert Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients