Wilms Tumor Protein

Preferred Label : Wilms Tumor Protein;

NCIt synonyms : WT33; WT1; WT1 Gene Product; WT1 Protein;

NCIt definition : Wilms tumor protein (449 aa, 49 kDa) is encoded by the human WT1 gene. This protein is involved in transcriptional regulation, embryonic morphogenesis and in both tumor suppression and tumorigenesis.;

NCIt note : Wilms tumor protein binds to the DNA sequence 5'-CGCCCCCGC-3'. (UniProt);

Details

Origin ID

C17549;

UMLS CUI

C3710770;

Currated CISMeF NLP mapping
- WT1 proteins [MeSH Descriptor]
- WT1 proteins [MeSH concept]
OMIM relation
- Wt1 transcription factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- WT1 protein, human [MeSH concept]
- WT1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- WT1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Kidney [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Interferon Signaling Modulation Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Tert Regulation Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Wilms Tumor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Embryogenesis [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Anti-HLA-A2-WT1/Anti-CD3 T-cell Engaging Bispecific Antibody RO7283420 [NCIt concept]
- Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells [NCIt concept]
- Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes [NCIt concept]
- Autologous WT1-directed CRISPR/Cas9-engineered TCR-T Cells NTLA-5001 [NCIt concept]
- Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes [NCIt concept]
- Galinpepimut-S [NCIt concept]
- Multi-antigen-directed Autologous T-cells NEXI-002 [NCIt concept]
- Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes [NCIt concept]
- Recombinant Anti-WT1 Immunotherapeutic GSK2302024A [NCIt concept]
- WT1 124-138 Peptide Vaccine [NCIt concept]
- WT1 126-134 Peptide Vaccine [NCIt concept]
- WT1 235-243 Peptide Vaccine [NCIt concept]
- WT1 247-261 Peptide Vaccine [NCIt concept]
- WT1 Analog Peptide Vaccine [NCIt concept]
- WT1 Peptide Vaccine WT2725 [NCIt concept]
- WT1 Peptide-loaded Allogeneic Dendritic Cell Vaccine [NCIt concept]
- WT1 Protein-derived Peptide Vaccine DSP-7888 [NCIt concept]
- WT1-A10/AS01B Immunotherapeutic GSK2130579A [NCIt concept]
- WT1-Sensitized Allogeneic T-Lymphocytes [NCIt concept]
- WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517 [NCIt concept]
- WT1-targeted IL-2-based Fusion Protein CUE-102 [NCIt concept]
- WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes [NCIt concept]
- WT1/PRAME/Survivin-specific T-cells MANA-312 [NCIt concept]

Keyword's position in hierarchy(ies) :

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