Preferred Label : WT1 Peptide-loaded Allogeneic Dendritic Cell Vaccine;
NCIt synonyms : Wilms Tumor 1 Peptide-loaded Allogeneic Dendritic Cell Vaccine; WT1 Peptide-loaded Allogeneic DC Vaccine;
NCIt definition : A cell-based cancer vaccine composed of donor-derived dendritic cells (DCs) loaded
with three, human leukocyte antigen A2 (HLA-A2)-binding peptides derived from the
human tumor-associated antigen (TAA) Wilms tumor protein 1 (WT1), with potential immunomodulating
and antineoplastic activities. Upon vaccination, WT1 peptide-loaded allogeneic DC
vaccine exposes the immune system to WT1-derived peptides and may stimulate the host
immune system to mount a cytotoxic T-lymphocyte (CTL) response against WT1-expressing
cancer cells, which could result in tumor cell lysis. WT1, a transcription factor,
is overexpressed in leukemic cells and in various solid tumors, and only minimally
in normal tissues; its expression often correlates with disease progression and poor
prognosis. HLA-A2 is an MHC class I molecule that presents antigenic peptides to CD8
T-cells; restricting the peptides to those epitopes that bind most efficiently to
HLA-A2 may improve antigenic peptide immunogenicity.;
Origin ID : C120185;
UMLS CUI : C3897182;
Semantic type(s)
- concept_is_in_subset
- has_target
