NCIt definition : A peptide cancer vaccine comprised of peptides derived from the Wilms tumor gene 1
(WT1) protein, with potential immunomodulating and antineoplastic activities. Upon
administration, WT1 protein-derived peptide vaccine DSP-7888 may induce a specific
cytotoxic T-lymphocyte (CTL) response against WT1-overexpressing tumor cells. In addition,
DSP-7888 induces a helper T-lymphocyte-mediated immune response against WT1 expressing
tumor cells. WT1 protein, a zinc finger DNA-binding protein and transcription factor,
is overexpressed in leukemic cells and in many non-hematological solid tumors.;