" /> Multi-antigen-directed Autologous T-cells NEXI-002 - CISMeF





Preferred Label : Multi-antigen-directed Autologous T-cells NEXI-002;

NCIt synonyms : Autologous MM-associated Antigens Specific T Cells NEXI-002; NEXI-002 T Cells; TAA Primed Antigen-specific CD8 T Cells NEXI-002;

NCIt definition : A preparation of autologous T-cells targeting several multiple myeloma (MM)-associated antigens, with potential immunomodulating and antineoplastic activities. Peripheral blood mononuclear cells (PBMC) from the patient are collected and ex vivo exposed to nanoparticles that mimic antigen-presenting cells (APCs) loaded with multiple MM-associated antigens, including Wilms' tumor 1 (WT1), CD138 (syndecan-1; SDC1), cancer-testis antigen NY-ESO-1 and CS1 (CD319; CRACC; SLAMF7), and are further enriched and expanded ex-vivo before being re-introduced into the patient. Upon administration, the multi-antigen-directed autologous T-cells NEXI-002 are re-introduced into the patient, where they target and kill tumor cells expressing these antigens.;

Molecule name : NEXI 002; NEXI-002;

NCI Metathesaurus CUI : CL1407787;

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15/05/2024


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