SLAM Family Member 7

Preferred Label : SLAM Family Member 7;

NCIt synonyms : CD319; Novel Ly9; CRACC; CD Antigen CD319; Protein 19A; Membrane Protein FOAP-12; CD2-Like Receptor-Activating Cytotoxic Cells; CD319 Antigen; CD2 Subset 1; CD2-Like Receptor Activating Cytotoxic Cells; SLAMF7; CS1;

CISMeF synonym : CD319; CRACC;

NCIt definition : SLAM family member 7 (335 aa, 37 kDa) is encoded by the human SLAMF7 gene. This protein is involved in signal transduction that promotes the activation of natural killer cells.;

NCIt note : SLAM family member 7 may be a target for elotuzumab in the treatment of multiple myeloma.; There are 3 isoforms of SLAM family member 7 that result from alternative splicing. SLAM family member 7 isoform 3 is known as 19A24 protein and does not have the same natural killer cell activation activity as the canonical isoform 1. (UniProt);

Details

Origin ID

C95308;

UMLS CUI

C1099412;

OMIM relation
- Slam family, member 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- SLAMF7 protein, human [MeSH concept]
- SLAMF7 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- SLAMF7 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- NK Cell Activation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells [NCIt concept]
- Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A [NCIt concept]
- Autologous Anti-BCMA/CS1 Bispecific CAR-T Cells [NCIt concept]
- Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes [NCIt concept]
- Autologous Anti-SLAMF7 CAR-expressing T-cells [NCIt concept]
- Azintuxizumab Vedotin [NCIt concept]
- Elotuzumab [NCIt concept]
- Multi-antigen-directed Autologous T-cells NEXI-002 [NCIt concept]
- XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410 [NCIt concept]

Keyword's position in hierarchy(ies) :

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