Preferred Label : Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A;
NCIt synonyms : Allogenic Engineered T-cells Expressing Anti- CS1 CAR UCARTCS1A; Allogeneic Gene-edited CAR T-Cells UCARTCS1A; UCARTCS1A Cells; Allogeneic TALEN Gene-edited CAR T-Cells UCARTCS1A;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like
effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified
to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen
(TAA) human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential
immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CS1-specific
universal CAR-expressing T-lymphocytes UCARTCS1A, these cells target and bind to cancer
cells expressing CS1. This induces selective toxicity in and causes lysis of CS1-expressing
tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM)
family of transmembrane receptors that modulate the function of immune cells through
immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins.
SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed
on healthy immune cells.;
Molecule name : UCART CS1A; UCART-CS1A;
NCI Metathesaurus CUI : CL978955;
Origin ID : C165661;
UMLS CUI : C5237351;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
