Preferred Label : Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes;
NCIt synonyms : Multi-TAA Specific T Cells; Donor-derived Multi-Tumor Associated Antigen (multiTAA)-Specific T Cells;
NCIt definition : Allogeneic T-lymphocytes specifically reactive to the tumor-associated antigens (TAAs)
human Wilms tumor protein-1 (WT1), Preferentially Expressed Antigen in Melanoma (PRAME),
the cancer-testis antigen NY-ESO-1, and survivin, with potential antineoplastic activity.
Donor derived T-cells are mixed, ex vivo, with protein fragments derived from the
TAAs WT1, PRAME, NY-ESO-1, and survivin. Upon intravenous administration, the donor-derived
WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes recognize and kill cancer cells
expressing these TAAs. WT1, NY-ESO-1, PRAME, and survivin, are expressed on certain
tumor cell types and play key role in tumor cell proliferation and survival.;
NCI Metathesaurus CUI : CL498211;
Origin ID : C123817;
UMLS CUI : C4087054;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
