Galinpepimut-S

Preferred Label : Galinpepimut-S;

NCIt synonyms : WT-1 Analog Peptide Vaccine SLS-001; SLS-001;

NCIt definition : A peptide cancer vaccine comprised of four peptide chains derived from the Wilms' tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic activities. Upon administration, galinpepimut-S, which is comprised of one WT1-derived peptide (WT-A1) that may stimulate CD8-positive T-cell responses; two WT1 peptides (WT1-427 long, WT1-331 long) that may stimulate CD4-positive T-cell responses; and one modified peptide (WT1-122A1 long) that may stimulate both CD4-positive and CD8-positive T-cells, may elicit a targeted innate immune response against WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding protein and transcription factor, is overexpressed in leukemic cells and in many non-hematological solid tumors.;

UNII : 12R66419FZ;

Molecule name : SLS001; SLS 001; 3D189;

NCI Metathesaurus CUI : CL970406;

Details

Origin ID

C161778;

UMLS CUI

C5206092;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Wilms Tumor Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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