Preferred Label : Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes;
NCIt definition : Autologous, human CD8 T-lymphocytes, comprised of both central memory T-cells (Tcm)
and naïve T-cells (Tn), that are transduced, ex vivo, with a self-inactivating (SIN)
lentiviral vector encoding a high-affinity T-cell receptor (TCRc4) specific for the
human tumor antigen Wilms tumor 1 (WT1) epitope 126-134 (RMFPNAPYL), with potential
antineoplastic activity. Upon isolation of peripheral blood lymphocytes (PBLs), transduction,
expansion ex vivo, priming of the Tn subset, but not the Tcm subset, with interleukin-21
(IL-21) and reintroduction of equal amounts of Tcm and Tn cells into the patient,
WT1-TCRc4 gene-transduced CD8-positive Tcm/Tn lymphocytes redirect T-lymphocytes to
WT1-expressing tumor cells and specifically bind to and lyse those cells. This inhibits
proliferation of WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding
transcriptional regulator, is overexpressed in most leukemias and various solid tumors,
while expression in normal, healthy tissues is very limited; its expression is correlated
with aggressiveness and poor prognosis.;
Origin ID : C121308;
UMLS CUI : C4055421;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
