NCIt definition : A peptide vaccine comprised of an epitope of human Wilms tumor 1 (WT-1) with potential
antineoplastic activity. WT-1, a transcription factor, is overexpressed in most types
of leukemia and in some solid cancers. Vaccination with the WT-1 analog peptide vaccine
may induce a cytotoxic T-lymphocyte (CTL) response against WT-1 expressing cells,
resulting in cell lysis and inhibition of cancer cell proliferation.;