Preferred Label : WT1/PRAME/Survivin-specific T-cells MANA-312;
NCIt synonyms : WT1/PRAME/Survivin-specific T Cells MANA-312; Multi-antigen-specific T-cells MANA 312;
NCIt definition : A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that are reactive
to multiple tumor-associated antigens (TAAs), with potential immunomodulating and
antineoplastic activities. T-cells derived from allogeneic donor leukocytes are stimulated
with monocyte-derived dendritic cells (DCs) that are pulsed with a mix of peptides
derived from the three TAAs Wilms tumor 1 (WT1), preferentially expressed antigen
of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting
protein 4; OIP-4) and survivin (baculoviral IAP repeat-containing protein 5; BIRC5).
The antigen-specific T-cells are subsequently expanded. Upon administration of WT1/PRAME/survivin-specific
T-cells MANA 312, the T-cells recognize, induce a T-cell mediated immune response
in and induce lysis of tumor cells that express WT1, PRAME and/or survivin. In addition,
tumor cell lysis induces the release of a broader set of tumor antigens, thereby further
stimulating the immune system to exert an anti-tumor T-cell-mediated immune response.
WT1, PRAME and survivin, overexpressed in a variety of tumor cell types, play key
roles in tumor cell proliferation.;
Molecule name : MANA 312; MANA-312;
NCI Metathesaurus CUI : CL1662249;
Origin ID : C179500;
UMLS CUI : C5555727;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
