" /> Baculoviral IAP Repeat-Containing Protein 5 - CISMeF





Preferred Label : Baculoviral IAP Repeat-Containing Protein 5;

NCIt synonyms : IAP4; Baculoviral IAP Repeat-Containing 5 (Survivin); Apoptosis Inhibitor Survivin; BIRC5; Survivin; Apoptosis Inhibitor 4; EPR-1; API4;

NCIt definition : Baculoviral IAP repeat-containing protein 5 (142 aa, 16 kDa) is encoded by the human BIRC5 gene. This protein plays a role in the regulation of both apoptosis and the cell cycle.;

NCIt note : Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. It is abundantly expressed in various human cancers but undetectable in normal differentiated tissues. Survivin associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. It is physically associated with cyclin-dependent kinase p34(cdc2) on the mitotic apparatus, and is phosphorylated on Thr(34) by p34(cdc2)-cyclin B1 in vitro and in vivo. Therefore, survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis. (from LocusLink);

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12/05/2024


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