" /> IAP Family Protein - CISMeF





Preferred Label : IAP Family Protein;

NCIt synonyms : Inhibitor of Apoptosis Protein; IAP Protein;

NCIt definition : A family of proteins that are related structurally and functionally and are inhibitors of apoptosis.;

NCIt note : IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI);

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14/05/2024


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