Preferred Label : Birinapant;
NCIt synonyms : Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-,(2S,2'S)-;
NCIt definition : A synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived
activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein)
family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP
antagonist, birinapant selectively binds to and inhibits the activity of IAPs, such
as X chromosome-linked IAP (XIAP) and cellular IAPs 1 (cIAP1) and 2 (cIAP2), with
a greater effect on cIAP1 than cIAP2. Since IAPs shield cancer cells from the apoptosis
process, this agent may restore and promote the induction of apoptosis through apoptotic
signaling pathways in cancer cells and inactivate the nuclear factor-kappa B (NF-kB)-mediated
survival pathway. IAPs are overexpressed by many cancer cell types. They are able
to suppress apoptosis by binding to, via their baculoviral lAP repeat (BIR) domains,
and inhibiting active caspases-3, -7 and -9. IAP overexpression promotes both cancer
cell survival and chemotherapy resistance.;
UNII : 6O4Z07B57R;
InChIKey : PKWRMUKBEYJEIX-DXXQBUJASA-N;
CAS number : 1260251-31-7;
Molecule name : TL32711;
Origin ID : C88295;
UMLS CUI : C3658709;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
