Baculoviral IAP Repeat-Containing Protein 2

Preferred Label : Baculoviral IAP Repeat-Containing Protein 2;

NCIt synonyms : RING Finger Protein 48; HIAP-2; BIRC2; Cellular Inhibitor of Apoptosis-1; HIAP2; Mammalian IAP Homolog B; IAP Homolog B; Apoptosis Inhibitor 1; Inhibitor Of Apoptosis Protein 2; C-IAP1; TNFR2-TRAF-Signaling Complex Protein 2; Human Inhibitor of Apoptosis Protein-2; Baculoviral IAP Repeat-Containing Protein-2;

NCIt definition : Baculoviral IAP repeat-containing protein 2 (618 aa, 70 kDa) is encoded by the human BIRC2 gene. This protein plays a role in the regulation of apoptosis.;

NCIt note : Encoded by BIRC2 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 2 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.;

Details

Origin ID

C20931;

UMLS CUI

C1531411;

Currated CISMeF NLP mapping
- Baculoviral IAP Repeat-Containing 2 Protein [MeSH concept]
OMIM relation
- Baculoviral iap repeat-containing protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BIRC2 protein, human [MeSH Supplementary Concept]
- BIRC2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BIRC2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- IAP Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BIR Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caspase Cascade Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
is_target
- Dasminapant [NCIt concept]
- IAP Antagonist TQB3728 [NCIt concept]
- SMAC Mimetic BI 891065 [NCIt concept]
- Smac Mimetic BGB-24714 [NCIt concept]
- Smac Mimetic GDC-0152 [NCIt concept]
- Smac Mimetic LCL161 [NCIt concept]
- Tolinapant [NCIt concept]
- Xevinapant [NCIt concept]

Keyword's position in hierarchy(ies) :

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