Baculoviral IAP Repeat-Containing Protein 7

Preferred Label : Baculoviral IAP Repeat-Containing Protein 7;

NCIt synonyms : Kidney Inhibitor of Apoptosis; Melanoma Inhibitor of Apoptosis Protein; Melanoma Inhibitor of Apoptosis; RING Finger Protein 50; BIRC7; Livin; ML-IAP; Kidney Inhibitor of Apoptosis Protein; KIAP;

NCIt definition : Baculoviral IAP repeat-containing protein 7 (298 aa, 33 kDa) is encoded by the human BIRC7 gene. This protein plays a role in both signal transduction and the inhibition of apoptosis.;

NCIt note : Encoded by BIRC7 Gene, Livin is a potent anti-apoptotic protein and caspase inhibitor with pleiotropic effects on apoptosis induced by various stimuli. BIRC7 anti-apoptotic activity is achieved by two mechanisms: TAK1-dependent JNK1 activation and caspase inhibition. Induced by a death stimulus, processed and activated SMAC interacts with the BIRC7 BIR (baculovirus IAP repeat) domain to abrogate BIRC7 inhibition of apoptosis. Alpha and beta BIRC7 splice variants have different biological properties and tissue distribution, though both have a significant anti-apoptotic activity. (NCI);

Details

Origin ID

C20951;

UMLS CUI

C0964024;

OMIM relation
- Baculoviral iap repeat-containing protein 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BIRC7 protein, human [MeSH Supplementary Concept]
- BIRC7 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BIRC7 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- IAP Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BIR Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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